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N- vs O-alkylation in 2(1H)-quinolinone derivatives

✍ Scribed by Zhao-Xia Guo; Andrew N Cammidge; Alexander McKillop; David C Horwell

Book ID: 104262204
Publisher: Elsevier Science
Year: 1999
Tongue: French
Weight: 181 KB
Volume: 40
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(99)01422-7

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✦ Synopsis

N-vs O-alkylation reactions of 8-benzyloxy-2(1H)-quinolinone have been investigated using both classical and phase transfer conditions. The influence of reaction solvents/conditions was found to have a dramatic effect on selectivity, with opposite trends to that observed for 2-pyridone alkylation.

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