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Synthesis of Carbocyclic Pyrimidine Nucleosides Using the Mitsunobu Reaction: O2- vs. N1-Alkylation

✍ Scribed by Elías Quezada; Dolores Viña; Giovanna Delogu; Fernanda Borges; Lourdes Santana; Eugenio Uriarte

Publisher: John Wiley and Sons
Year: 2010
Tongue: German
Weight: 159 KB
Volume: 93
Category: Article
ISSN: 0018-019X
DOI: 10.1002/hlca.200900242

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✦ Synopsis

Abstract

The Mitsunobu reaction is an important tool in carbocyclic nucleoside chemistry for the direct coupling of alcohols with heterocyclic bases under mild conditions. Chemical evidences for an unusual competitive O^2^‐ vs. N^1^‐alkylation of 3‐substituted pyrimidines is presented.

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