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Synthesis of 2-arylquinolin-4(1H)-ones and their transformation to N-alkylated and O-alkylated derivatives

โœ Scribed by Malose J. Mphahlele


Publisher
Journal of Heterocyclic Chemistry
Year
2010
Tongue
English
Weight
208 KB
Volume
47
Category
Article
ISSN
0022-152X

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โœฆ Synopsis


Abstract

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2โ€Arylโ€4โ€quinolones are versatile synthetic intermediates and several articles continue to appear in literature describing their synthesis, chemical transformation, structural properties, and biological activities. Their versatility as synthetic intermediates is a consequence of 4โ€quinolone moiety, which contains several reactive centers (positions 1, 3, and 4) for possible functionalization and can also enable different degree of unsaturation. In this review, we describe methods developed toโ€date for the synthesis of 2โ€arylquinolinโ€4(1__H__)โ€ones and their Nโ€alkylated and Oโ€alkylated derivatives. J. Heterocyclic Chem., 2010.


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