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N-acetyltransferase (NAT) 2 acetylator status and age of onset in patients with hereditary nonpolyposis colorectal cancer (HNPCC)

✍ Scribed by Steffen Pistorius; Heike Görgens; Stefan Krüger; Christoph Engel; Elisabeth Mangold; Constanze Pagenstecher; Elke Holinski-Feder; Gabriela Moeslein; Magnus von Knebel Doeberitz; Josef Rüschoff; Judith Karner-Hanusch; Hans-Detlev Saeger; Hans K. Schackert; The German HNPCC-Consortium


Book ID
116334005
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
183 KB
Volume
241
Category
Article
ISSN
0304-3835

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Fourteen Italian families affected with hereditary nonpolyposis colorectal cancer (HNPCC) were screened for germline mutations at three DNA mismatch repair (MMR) genes, MSH2, MLH1, and GTBP, by using a combination of different methods that included an in vitro synthesized protein assay, single-stran