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Germline mutations of EXO1 gene in patients with hereditary nonpolyposis colorectal cancer (HNPCC) and atypical HNPCC forms

✍ Scribed by Ying Wu; Maran J.W. Berends; Jan G. Post; Rob G.J. Mensink; Edwin Verlind; Tineke Van Der Sluis; Claudia Kempinga; Rolf H. Sijmons; Ate G.J. Van Der Zee; Harry Hollema; Jan H. Kleibeuker; Charles H.C.M. Buys; Robert M.W. Hofstra


Book ID
119756257
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
157 KB
Volume
120
Category
Article
ISSN
0016-5085

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Mutations in hMSH2 and hMLH1 genes were analyzed in patients from 11 Japanese families that had been diagnosed as carrying hereditary nonpolyposis colorectal cancer (HNPCC) by clinical examination. Germ line mutations of hMSH2 gene were identified in 5 independent families in which colorectal (87% o