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DHPLC mutation analysis of the hereditary nonpolyposis colon cancer (HNPCC) genes hMLH1 and hMSH2

✍ Scribed by Elke Holinski-Feder; Y Müller-Koch; W Friedl; G Moeslein; G Keller; J Plaschke; W Ballhausen; M Gross; K Baldwin-Jedele; M Jungck; E Mangold; H Vogelsang; H.-K Schackert; P Lohsea; J Murken; Th Meitinger

Book ID
117331054
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
218 KB
Volume
47
Category
Article
ISSN
0165-022X

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Germ line mutations of hMSH2 and hMLH1 genes in Japanese families with hereditary nonpolyposis colorectal cancer (HNPCC): usefulness of DNA analysis for screening and diagnosis of HNPCC patients
✍ M. Miyaki; M. Konishi; M. Muraoka; R. Kikuchi-Yanoshita; K. Tanaka; T. Iwama; T. 📂 Article 📅 1995 🏛 Springer 🌐 English ⚖ 848 KB

Mutations in hMSH2 and hMLH1 genes were analyzed in patients from 11 Japanese families that had been diagnosed as carrying hereditary nonpolyposis colorectal cancer (HNPCC) by clinical examination. Germ line mutations of hMSH2 gene were identified in 5 independent families in which colorectal (87% o