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Hereditary non-polyposis colorectal cancer (HNPCC): Cancer patterns in germline mutation (hMSH2, hMLH1) positive (M+) and mutation negative (M−) families

✍ Scribed by Temple, LKF; Bapat, B; Madlensky, L; Redston, M; Hiruki, T; Cohen, Z; McLeod, RS; Gallinger, S


Book ID
122620397
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
163 KB
Volume
114
Category
Article
ISSN
0016-5085

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We have screened 17 Southern Sweden individuals/families with suspected hereditary non-polyposis colorectal cancer (HNPCC) for mutations in the DNA-mismatch repair genes hMLH1, hMSH2 and hMSH6 using denaturing gradient gel electrophoresis, protein truncation test and direct DNA sequencing. The famil