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N-acetylaspartylglutamate protects against transient focal cerebral ischemia in rats

✍ Scribed by Xi-Chun M Lu; Zhaocheng Tang; Weilin Liu; Qian Lin; Barbara S Slusher

Book ID
114013491
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
438 KB
Volume
408
Category
Article
ISSN
0014-2999

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## Abstract Heme oxygenase‐1 (HO1) catalyzes oxidation of the heme molecule in concert with NADPH‐cytochrome P450 reductase following the specific cleavage of heme into carbon monoxide, iron, and biliverdin, which is rapidly metabolized to bilirubin. HO1 is a stress‐inducible protein that protects