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Dextromethorphan protects against cerebral injury following transient, but not permanent, focal ischemia in rats

โœ Scribed by Paul Britton; X.-C.May Lu; Michael S Laskosky; Frank C Tortella


Book ID
117174985
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
904 KB
Volume
60
Category
Article
ISSN
0024-3205

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The neuroprotective effect of mexiletine (Mex), a potent Na ุ‰ channel blocker which decreases neuronal energy demands and prevents energy depletion during ischemia, was evaluated in Wistar rats subjected to permanent middle cerebral artery (MCA) occlusion. Postmortem infarct volumes were determined