𝔖 Bobbio Scriptorium
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Cortical Spreading Depression Protects Against Subsequent Focal Cerebral Ischemia in Rats

✍ Scribed by Matsushima, Kazushi; Hogan, Matthew J.; Hakim, Antoine M.

Book ID
110078620
Publisher
Nature Publishing Group
Year
1996
Tongue
English
Weight
327 KB
Volume
16
Category
Article
ISSN
0271-678X

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## Abstract Heme oxygenase‐1 (HO1) catalyzes oxidation of the heme molecule in concert with NADPH‐cytochrome P450 reductase following the specific cleavage of heme into carbon monoxide, iron, and biliverdin, which is rapidly metabolized to bilirubin. HO1 is a stress‐inducible protein that protects