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MYST3/CREBBP (MOZ/CBP) and CREBBP/MYST3 (CBP/MOZ) transcripts in AML with t(8;16)(p11;p13)

✍ Scribed by H. H. Schmidt


Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
36 KB
Volume
42
Category
Article
ISSN
1045-2257

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## Abstract The t(8;16)(p11;p13) fuses the __MOZ__ (__MYST3__) gene at 8p11 with __CBP__ (__CREBBP__) at 16p13 and is associated with an infrequent but well‐defined type of acute myeloid leukemia (AML) that has unique morphocytochemical findings (monocytoid blast morphology with erythrophagocytosis

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## Abstract The t(8;16)(p11;p13), which is strongly associated with acute myeloid leukemia (AML) displaying monocytic differentiation, erythrophagocytosis by the leukemic cells, and a poor response to chemotherapy, fuses the __MOZ__ gene (8p11) with the __CBP__ gene (16p13). Although genomic rearra

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We report on a novel chromosomal aberration, inv(8)(p11q24), in an M5 acute myeloid leukemia. We show by fluorescence in situ hybridization and Southern blot analyses that a t(8;16)(p11;p13) is masked by this inversion. The translocation targets the MOZ gene from the 8p11 and the CBP gene from the 1