Mutations of HBV enhancer II, core promoter and precore regions in chronic HBV infection
β Scribed by Kim, Yun Soo; Kim, Seok; Moon, Jong Ho; Cho, Young Deok; Lee, Moon Sung; Shim, Chan Sup
- Book ID
- 122429910
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 173 KB
- Volume
- 118
- Category
- Article
- ISSN
- 0016-5085
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## Abstract One hundred fortyβtwo precore/core sequences were obtained from Gambian chronic hepatitis B virus (HBV) carriers and the predominant variants defined. The two point mutations, from A to T and G to A at nt positions 1762 and 1764 in the basic core promoter region, were found in only 7/99
## Abstract Ten hepatitis B surface antigen seropositive carriers (5 asymptomatic and 5 with chronic liver disease) were tested for HBeAg/antiβHBe and for HBVβDNA using the polymerase chain reaction. Five were DNAβpositive, 2 with HBeAg and 3 with antiβHBe. Nucleotide sequences were determined for