942 HBV genotypes and precore/core promoter mutations in patients with chronic HBV infection
β Scribed by Evangelini Dimou; Andreas Laras; George V. Papatheodoridis; Stefanos J. Hadziyannis
- Book ID
- 119530844
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 250 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0270-9139
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## Abstract One hundred fortyβtwo precore/core sequences were obtained from Gambian chronic hepatitis B virus (HBV) carriers and the predominant variants defined. The two point mutations, from A to T and G to A at nt positions 1762 and 1764 in the basic core promoter region, were found in only 7/99
## Abstract Ten hepatitis B surface antigen seropositive carriers (5 asymptomatic and 5 with chronic liver disease) were tested for HBeAg/antiβHBe and for HBVβDNA using the polymerase chain reaction. Five were DNAβpositive, 2 with HBeAg and 3 with antiβHBe. Nucleotide sequences were determined for