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Precore and core mutations in HBV from individuals in india with chronic infection

✍ Scribed by T. Valliammai; Dr. Tim J. Harrison; Arie J. Zuckerman; S. P. Thyagarajan

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
419 KB
Volume
45
Category
Article
ISSN
0146-6615

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✦ Synopsis

Abstract

Ten hepatitis B surface antigen seropositive carriers (5 asymptomatic and 5 with chronic liver disease) were tested for HBeAg/anti‐HBe and for HBV‐DNA using the polymerase chain reaction. Five were DNA‐positive, 2 with HBeAg and 3 with anti‐HBe. Nucleotide sequences were determined for these 5 cases. Hepatitis B virus DNA from one cirrhotic carrier with anti‐HBe had a mutation in the precore region (nucleotide position 1862) which may affect signal peptide cleavage and HBeAg synthesis. In the other 2 anti‐HBe‐ and DNA‐positive cases, a cirrhotic carrier and an asymptomatic case, there was a mutation at nucleotide position 1896 leading to a termination codon in the precore region. In all 5 patients, except for one or two missense mutations, there was no significant variation in the core region. © 1995 Wiley‐Liss, Inc.

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