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Mutations in Copper-Zinc Superoxide Dismutase that Cause Amyotrophic Lateral Sclerosis Alter the Zinc Binding Site and the Redox Behavior of the Protein

✍ Scribed by Thomas J. Lyons, Hongbin Liu, Joy J. Goto, Aram Nersissian, James A. Roe, Janet A. Graden, Carla Cafe, Lisa M. Ellerby, Dale E. Bredesen, Edith Butler Gralla and Joan Selverstone Valentine


Book ID
123640199
Publisher
National Academy of Sciences
Year
1996
Tongue
English
Weight
893 KB
Volume
93
Category
Article
ISSN
0027-8424

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## Abstract The demonstration of a genetic linkage between the copper‐zinc superoxide dismutase (SOD1) gene and familial amyotrophic lateral sclerosis has aroused interest in the role of SOD1 in motoneuronal death. We investigated the expression of the human SOD1 gene at a cellular level in the mot