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Limited corticospinal tract involvement in amyotrophic lateral sclerosis subjects with the A4V mutation in the copper/zinc superoxide dismutase gene

✍ Scribed by Dr M. E. Cudkowicz; D. McKenna-Yasek; C. Chen; E. T. Hedley-Whyte; R. H. Brown Jr.

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
838 KB
Volume
43
Category
Article
ISSN
0364-5134

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✍ Kazutoshi Nishiyama; Dr. Shigeo Murayama; Shin Kwak; Ichiro Kanazawa 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 659 KB

## Abstract The demonstration of a genetic linkage between the copper‐zinc superoxide dismutase (SOD1) gene and familial amyotrophic lateral sclerosis has aroused interest in the role of SOD1 in motoneuronal death. We investigated the expression of the human SOD1 gene at a cellular level in the mot