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The metal binding properties of the zinc site of yeast copper-zinc superoxide dismutase: implications for amyotrophic lateral sclerosis

✍ Scribed by T. J. Lyons; A. Nersissian; H. Huang; H. Yeom; C. R. Nishida; J. A. Graden; E. B. Gralla; J. S. Valentine

Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
403 KB
Volume
5
Category
Article
ISSN
1432-1327

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## Abstract The demonstration of a genetic linkage between the copper‐zinc superoxide dismutase (SOD1) gene and familial amyotrophic lateral sclerosis has aroused interest in the role of SOD1 in motoneuronal death. We investigated the expression of the human SOD1 gene at a cellular level in the mot