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Mutation screening of RET proto-oncogene in a family with medullary thyroid carcinoma, marfanoid habitus and pheochromocytoma; from clinically MEN2B to genetically MEN2A syndrome

✍ Scribed by Hasani-Ranjbar, Shirin; Amoli, Mahsa M.


Book ID
113093198
Publisher
Springer
Year
2012
Tongue
English
Weight
147 KB
Volume
42
Category
Article
ISSN
0969-711X

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Communicated by B w e A.J. Pondei Multiple endocrine neoplasia type 2 [MEN 21 is an autosomal dominant cancer syndrome with two subtypes, 2A and 2B. MEN 2A and medullary thyroid cancer [MTC] are caused by >25 different point mutations in exons 10, 11, and 13 of the RET proto-oncogene, whereas MEN 2B

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