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Analysis of RET proto-oncogene abnormalities in patients with MEN 2A, MEN 2B, familial or sporadic medullary thyroid carcinoma

โœ Scribed by Chiefari, E.; Russo, D.; Giuffrida, D.; Zampa, G. A.; Meringolo, D.; Arturi, F.; Chiodini, I.; Bianchi, D.; Attard, M.; Trischitta, V.; Bruno, R.; Giannasio, P.; Pontecorvi, A.; Filetti, Sebastiano


Book ID
125337727
Publisher
Springer-Verlag
Year
1998
Tongue
English
Weight
763 KB
Volume
21
Category
Article
ISSN
0391-4097

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Communicated by B w e A.J. Pondei Multiple endocrine neoplasia type 2 [MEN 21 is an autosomal dominant cancer syndrome with two subtypes, 2A and 2B. MEN 2A and medullary thyroid cancer [MTC] are caused by >25 different point mutations in exons 10, 11, and 13 of the RET proto-oncogene, whereas MEN 2B