A mutation in the RET proto-oncogene associated with multiple endocrine neoplasia type 2B and sporadic medullary thyroid carcinoma
β Scribed by Hofstra, Robert M. W.; Landsvater, Rudy M.; Ceccherini, Isabella; Stulp, Rein P.; Stelwagen, Tineke; Luo, Yin; Pasini, Barbara; Hoppener, Jo W. M.; van Amstel, Hans Kristian Ploos; Romeo, Giovanni
- Book ID
- 109787529
- Publisher
- Nature Publishing Group
- Year
- 1994
- Tongue
- English
- Weight
- 244 KB
- Volume
- 367
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/367375a0
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Germline and somatic mutations of the RET proto-oncogene are important pathogenetic factors in hereditary and sporadic forms of medullary thyroid carcinoma (MTC). We have therefore analysed exons 10, I I. 13, 14 and 16 of this gene in 85 individuals from 16 Austrian families who, according to clinic