A Rapid Screening Method for the Detection of Mutations in the RET Proto-oncogene in Multiple Endocrine Neoplasia Type 2A and Familial Medullary Thyroid Carcinoma Families
โ Scribed by Debbie J. Marsh; Bruce G. Robinson; Scott Andrew; Anne-Louise Richardson; Ruth Pojer; Margaret Schnitzler; Lois M. Mulligan; Valentine J. Hyland
- Book ID
- 115612375
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 237 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0888-7543
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Communicated by Kenneth K. Kidd Gennline missense mutations within the coding region of the RET proto-oncogene have recently been described in patients with the dominantly inherited cancer syndromes, multiple endocrine neoplasia type 2a (MEN 2a) and familial medullary thyroid carcinoma (FMTC). To da
Communicated by B w e A.J. Pondei Multiple endocrine neoplasia type 2 [MEN 21 is an autosomal dominant cancer syndrome with two subtypes, 2A and 2B. MEN 2A and medullary thyroid cancer [MTC] are caused by >25 different point mutations in exons 10, 11, and 13 of the RET proto-oncogene, whereas MEN 2B