Biological and biochemical properties of Ret with kinase domain mutations identified in multiple endocrine neoplasia type 2B and familial medullary thyroid carcinoma
β Scribed by Iwashita, Toshihide; Kato, Masashi; Murakami, Hideki; Asai, Naoya; Ishiguro, Yoshihiro; Ito, Shinji; Iwata, Yosuke; Kawai, Kumi; Asai, Masami; Kurokawa, Kei
- Book ID
- 110062167
- Publisher
- Nature Publishing Group
- Year
- 1999
- Tongue
- English
- Weight
- 217 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0950-9232
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π SIMILAR VOLUMES
Communicated by Kenneth K. Kidd Gennline missense mutations within the coding region of the RET proto-oncogene have recently been described in patients with the dominantly inherited cancer syndromes, multiple endocrine neoplasia type 2a (MEN 2a) and familial medullary thyroid carcinoma (FMTC). To da
Communicated by B w e A.J. Pondei Multiple endocrine neoplasia type 2 [MEN 21 is an autosomal dominant cancer syndrome with two subtypes, 2A and 2B. MEN 2A and medullary thyroid cancer [MTC] are caused by >25 different point mutations in exons 10, 11, and 13 of the RET proto-oncogene, whereas MEN 2B