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Biological and biochemical properties of Ret with kinase domain mutations identified in multiple endocrine neoplasia type 2B and familial medullary thyroid carcinoma

✍ Scribed by Iwashita, Toshihide; Kato, Masashi; Murakami, Hideki; Asai, Naoya; Ishiguro, Yoshihiro; Ito, Shinji; Iwata, Yosuke; Kawai, Kumi; Asai, Masami; Kurokawa, Kei


Book ID
110062167
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
217 KB
Volume
18
Category
Article
ISSN
0950-9232

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Communicated by B w e A.J. Pondei Multiple endocrine neoplasia type 2 [MEN 21 is an autosomal dominant cancer syndrome with two subtypes, 2A and 2B. MEN 2A and medullary thyroid cancer [MTC] are caused by >25 different point mutations in exons 10, 11, and 13 of the RET proto-oncogene, whereas MEN 2B