Mutation analysis ofParkin,PINK1andDJ-1genes in Chinese patients with sporadic early onset parkinsonism
β Scribed by Ji-feng Guo; Xue-wei Zhang; Li-luo Nie; Hai-nan Zhang; Bin Liao; Jing Li; Lei Wang; Xin-xiang Yan; Bei-sha Tang
- Book ID
- 106094797
- Publisher
- Springer
- Year
- 2010
- Tongue
- English
- Weight
- 185 KB
- Volume
- 257
- Category
- Article
- ISSN
- 0340-5354
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## Abstract Pathogenic __PINK1__ mutations have been described in PARK6βlinked Parkinson's disease (PD) patients of Asian origin. However, data on the frequency of __PINK1__ mutations in sporadic earlyβonset Parkinson's disease (EOPD) Asian patients are lacking. The objectives of this study were to
## Abstract Autosomal recessive earlyβonset Parkinsonism (AREP) has been associated with mutations in the __Parkin__, __PINK1__, __DJβ1__, and __ATP13A2__ genes. We studied the prevalence of mutations in all four genes in 29 Chinese unrelated families with AREP using direct sequencing analysis and
## Abstract Data on the frequency of __PINK1__ mutations in Brazilian patients with earlyβonset Parkinson's disease (EOPD) are lacking. The aim of this report was to investigate mutations of the __PINK1__ gene in a cohort of Brazilian patients with EOPD. Sixty consecutive familial or sporadic EOPD