## Abstract Pathogenic __PINK1__ mutations have been described in PARK6βlinked Parkinson's disease (PD) patients of Asian origin. However, data on the frequency of __PINK1__ mutations in sporadic earlyβonset Parkinson's disease (EOPD) Asian patients are lacking. The objectives of this study were to
PINK1 mutations are associated with sporadic early-onset parkinsonism
β Scribed by Enza Maria Valente; Sergio Salvi; Tamara Ialongo; Roberta Marongiu; Antonio Emanuele Elia; Viviana Caputo; Luigi Romito; Alberto Albanese; Bruno Dallapiccola; Anna Rita Bentivoglio
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 136 KB
- Volume
- 56
- Category
- Article
- ISSN
- 0364-5134
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Homozygous or compound heterozygous mutations in the __PINK1__ gene represent the second most frequent cause of autosomal recessive parkinsonism after __Parkin__. The phenotype differs from idiopathic Parkinson's disease for earlier onset, slower disease progression, and better response
## Abstract Data on the frequency of __PINK1__ mutations in Brazilian patients with earlyβonset Parkinson's disease (EOPD) are lacking. The aim of this report was to investigate mutations of the __PINK1__ gene in a cohort of Brazilian patients with EOPD. Sixty consecutive familial or sporadic EOPD