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Mutation analysis of the PTEN/MMAC1 gene in lung cancer

✍ Scribed by Forgacs, Eva; Biesterveld, Eric J; Sekido, Yoshitaka; Fong, Kwun; Muneer, Sabeeha; Wistuba, Ignacio I; Milchgrub, Sara; Brezinschek, Ruth; Virmani, Arvind; Gazdar, Adi F

Book ID
110061551
Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
453 KB
Volume
17
Category
Article
ISSN
0950-9232

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The PTEN/MMAC1/TEP1 gene has been isolated as a tumor suppressor gene that is altered in several types of human tumors including brain, breast, and prostate cancers. In the present study, we report PTEN/MMAC1/TEP1 alterations in human lung cancers. Intragenic homozygous deletions were detected in 6

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Recently, a putative tumor suppressor gene, PTEN/MMAC1, has been identified at chromosome 10q23.3, which encodes a 403 amino acid dual-specificity phosphatase containing a region of homology to tensin and auxillin. Somatic mutations of the PTEN/MMAC1 gene have been identified in a number of cancer c