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PTEN/MMAC1 mutations identified in small cell, but not in non-small cell lung cancers

✍ Scribed by Yokomizo, Akira; Tindall, Donald J; Drabkin, Harry; Gemmill, Robert; Franklin, Wilbur; Yang, Ping; Sugio, Kenji; Smith, David I; Liu, Wanguo

Book ID: 110061444
Publisher: Nature Publishing Group
Year: 1998
Tongue: English
Weight: 312 KB
Volume: 17
Category: Article
ISSN: 0950-9232
DOI: 10.1038/sj.onc.1201956

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## Abstract __TMS1__ (target of methylation‐induced silencing) is a CpG island‐associated gene that functions in the regulation of apoptosis and encodes a caspase recruitment domain, a recently described motif found in apoptotic signaling molecules. Recent evidence suggests that silencing of genes