Mutational analysis of the PTEN/MMAC1 gene in non-Hodgkin’s lymphoma
✍ Scribed by Nakahara, Y; Nagai, H; Kinoshita, T; Uchida, T; Hatano, S; Murate, T; Saito, H
- Book ID
- 110053921
- Publisher
- Nature Publishing Group
- Year
- 1998
- Tongue
- English
- Weight
- 103 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0887-6924
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The PTEN gene is involved in 10q23 deletions in several types of cancer, including glioma, melanoma, endometrial and prostate carcinomas. The PTEN gene product is a dual-specificity phosphatase with putative tumor suppressor function. Deletions and rearrangements of 10q22-25 have been reported in ϳ5
Recently, a putative tumor suppressor gene, PTEN/MMAC1, has been identified at chromosome 10q23.3, which encodes a 403 amino acid dual-specificity phosphatase containing a region of homology to tensin and auxillin. Somatic mutations of the PTEN/MMAC1 gene have been identified in a number of cancer c