Mutated genes in pancreatic cancer
β Scribed by Song-bing He; De-chun Li
- Book ID
- 107467012
- Publisher
- Chinese Anti-Cancer Association
- Year
- 2010
- Tongue
- English
- Weight
- 407 KB
- Volume
- 22
- Category
- Article
- ISSN
- 1000-9604
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Seventy-seven pancreatic adenocarcinomas (60 Spanish and 17 Italian) were tested for Ki-ras gene mutations by analysis of polymerase chain reaction amplified sequences. Mutations involving codon I 2 GGT; gly) were detected in I6 Italian and 46 second base and were G to A transitions GAT; asp) in 8 c
Mutations in codon I 2 of K-ras occur in a high proportion of pancreatic cancer cases. Although there is evidence that p53 mutations also occur in this tumor, few studies have been reported to date and no comparison has been made of K-ras and p53 mutations in the same tissues. Single-strand conforma
## Abstract We analyzed the adenomatous polyposis coli (__APC__) tumorsuppressor gene as one of the possible genes mutated in human pancreatic carcinomas. DNAs from 39 surgical specimens were subjected to singleβstrand conformation polymorphism analysis of polymerase chain reaction products and the