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Mutant debrisoquine hydroxylation genes in Parkinson's disease

✍ Scribed by Armstrong, M.; Daly, A.K.; Cholerton, S.; Idle, J.R.; Bateman, D.N.

Book ID: 122371581
Publisher: The Lancet
Year: 1992
Tongue: English
Weight: 305 KB
Volume: 339
Category: Article
ISSN: 0140-6736
DOI: 10.1016/0140-6736(92)90537-D

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## Abstract Impaired debrisoquine metabolism resulting from defects in the cytochrome P450 __CYP2D6__‐debrisoquine hydroxylase gene has been shown to be associated with the development of Parkinson's disease(PD). We studied two polymorphisms in this gene in 207 Chinese PD patients and 227 control s