## Abstract Impaired debrisoquine metabolism resulting from defects in the cytochrome P450 __CYP2D6__βdebrisoquine hydroxylase gene has been shown to be associated with the development of Parkinson's disease(PD). We studied two polymorphisms in this gene in 207 Chinese PD patients and 227 control s
Debrisoquine hydroxylase gene polymorphism and susceptibility to Parkinson's disease
β Scribed by Smith, C.A.D; Wolf, C.R; Gough, A.C; Spurr, N.K; Leigh, P.N; Summers, B.A; Harding, A.E; Maranganore, D.M; Sturman, S.G; Williams, A.C; Schapira, A.H.V
- Book ID
- 122458865
- Publisher
- The Lancet
- Year
- 1992
- Tongue
- English
- Weight
- 457 KB
- Volume
- 339
- Category
- Article
- ISSN
- 0140-6736
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Molecular genetic studies of the cytochrome P450 system enzyme CYP2D6, which hydroxylates debrisoquine, have indicated an excess of mutant alleles in large series of patients with Parkinson's disease (PD) when compared with controls. We have investigated C YP2D6 polymorphism in 91 patients with mult
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