Debrisoquine oxidation in Parkinson's disease
✍ Scribed by J. Kallio; R. J. Marttila; U. K. Rinne; V. Sonninen; E. Syvälahti
- Book ID
- 114783374
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 394 KB
- Volume
- 83
- Category
- Article
- ISSN
- 0001-6314
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## Abstract Impaired debrisoquine metabolism resulting from defects in the cytochrome P450 __CYP2D6__‐debrisoquine hydroxylase gene has been shown to be associated with the development of Parkinson's disease(PD). We studied two polymorphisms in this gene in 207 Chinese PD patients and 227 control s
Oxidative stress contributes to the cascade leading to dopamine cell degeneration in Parkinson's disease (PD). However, oxidative stress is intimately linked to other components of the degenerative process, such as mitochondrial dysfunction, excitotoxicity, nitric oxide toxicity and inflammation. It