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Mutagenicity of nitrofurantoin and furazolidone in Chinese hamster ovary cell strains

โœ Scribed by Ning Gao; Yi-Chang Ni; Janice R. Thornton-Manning; Peter P. Fu; Robert H. Heflich


Book ID
113255288
Publisher
Elsevier Science
Year
1989
Weight
410 KB
Volume
225
Category
Article
ISSN
0165-7992

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A strong teratogen-6-aminonicotinamide (6-AN)-was tested for its ability to induce cytotoxicity and mutagenicity in Chinese hamster ovary (CHO) cells. Tests were performed in the presence and absence of a metabolic activation system (S-9 mix). Cytotoxicity was evaluated in CHO cells by the total pro