Mutagenicity of algal metabolites of benzo(a)pyrene forSalmonella typhimurium
β Scribed by Schoeny, Rita ;Cody, Terence ;Radike, Martha ;Warshawsky, David
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 1985
- Weight
- 1019 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0192-2521
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3-hydroxy-benzo(a)pyrene (3-OH-B(a)P) and mutagenic activity in rat urine were determined after the oral administration of benzo(a)pyrene given in three repeated doses of 10, 20 and 50 pmol kg-'. The procedure for the determination of 3-OH-B(a)P consisted of enzymic hydrolysis, separation and HPLC-a
## Abstract Benzo(a)pyrene and benz(a)anthrancene which, in contrast to the Kβregion epoxides benzo(a)pyrene 4,5βoxide and benz(a)anthracene 5,6βoxide, are not mutagenic to Salmonella typhimurium TA 1537 in the absence of mammalian enzyme preparations, were activated by liver microsomes from C3H mi