3-hydroxy-benzo(a)pyrene (3-OH-B(a)P) and mutagenic activity in rat urine were determined after the oral administration of benzo(a)pyrene given in three repeated doses of 10, 20 and 50 pmol kg-'. The procedure for the determination of 3-OH-B(a)P consisted of enzymic hydrolysis, separation and HPLC-a
β¦ LIBER β¦
Rat nasal tissue activation of benzo(a)pyrene and 2-aminoanthracene to mutagens in salmonella typhimurium
β Scribed by Bond, James A. ;Li, Albert P.
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 1983
- Weight
- 493 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0192-2521
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## Abstract The effects of benzo[__a__]pyrene (B[__a__]P) on some drugβmetabolizing and antioxidant systems in liver, lung, and stomach were investigated in normal and protein malnutrition (PM) rats. PM significantly inhibited tissue glutathione (GSH) content and increased hepatic lipid peroxidatio