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Mutagenic action of benz(a)pyrene and its metabolites in a Salmonella typhimurium — Microsome test system in vitro

✍ Scribed by Yu. D. Tolcheev; I. A. Khitrovo; V. A. Koblyakov


Publisher
Springer US
Year
1980
Tongue
English
Weight
296 KB
Volume
90
Category
Article
ISSN
0007-4888

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Binding of dimethylaminoazobenzene metab
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## Abstract Incubating dimethylaminoazobenzene [aniline ring (U)^14^ C] (DAB), purified thymus DNA and rat liver microsomes led to a covalent binding of radioactivity to DNA and proteins, which implied the presence of bound DAB metabolites. This binding required an enzymatic activation. We studied