The homogeneity of rat liver microsomal cytochrome P-448 activity and its role in the activation of benzo[a]pyrene to mutagens
β Scribed by Caroline E. Phillipson; Costas Ioannides; David C.A. Barrett; Dennis V. Parke
- Publisher
- Elsevier Science
- Year
- 1985
- Tongue
- English
- Weight
- 602 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0020-711X
No coin nor oath required. For personal study only.
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## Abstract Metabolic activation and DNA adduct formation of the carcinogenic aromatic hydrocarbon dibenzo{__a__,__l__}pyrene (DBP) was investigated in human mammary carcinoma MCFβ7 cells and human cytochrome P450 (CYP) 1B1βexpressing Chinese hamster V79 cells in culture. It has been shown that DBP