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The covalent binding of cyclosporin a to rat liver macromolecules in vivo and in vitro: The role of cytochrome P-450

✍ Scribed by J. Fred Nagelkerke; Roeline B. Tijidens; Erik P. Schwarz; Marjolein F.G. Winters; Leendert C. Paul; Gerard J. Mulder


Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
383 KB
Volume
47
Category
Article
ISSN
0300-483X

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## Abstract ^14^C‐labelled carbon tetrachloride binds __in vivo__ to DNA of mouse liver and to ^r^RNA of rat liver if the animals have been pretreated with 3‐methylcholanthrene. A noticeable amount of radioactivity is also observed in liver proteins. In vitro carbon tetrachloride is activated by mi