The metabolism and covalent binding of 14 C-monocrotaline in Sprague-Dawley (SD) rat liver microsomes was investigated using the inducers dexamethasone, clotrimazole, pregnenolone-16β£-carbonitrile, and phenobarbital. Monocrotaline is a pyrrolizidine alkaloid (PA) that causes a syndrome in rats that
The covalent binding of cyclosporin a to rat liver macromolecules in vivo and in vitro: The role of cytochrome P-450
β Scribed by J. Fred Nagelkerke; Roeline B. Tijidens; Erik P. Schwarz; Marjolein F.G. Winters; Leendert C. Paul; Gerard J. Mulder
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- English
- Weight
- 383 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0300-483X
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
The influence of in vivo administration of detergents on the hepatic microsomal cytochrome P-450 system was studied in rat. Male Wistar rats were administered detergents, Emulgen 913 (50 mg or 100 mg kg-' of body weight (B.W.)), or sodium dodecylsulfate (SDS, 25 mg or 50 mg kg-' of B.W.) intraperito
## Abstract ^14^Cβlabelled carbon tetrachloride binds __in vivo__ to DNA of mouse liver and to ^r^RNA of rat liver if the animals have been pretreated with 3βmethylcholanthrene. A noticeable amount of radioactivity is also observed in liver proteins. In vitro carbon tetrachloride is activated by mi