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In vivo and in vitro binding of carbon tetrachloride with nucleic acids and proteins in rat and mouse liver

✍ Scribed by P. Rocchi; G. Prodi; S. Grilli; A. M. Ferreri

Publisher
John Wiley and Sons
Year
1973
Tongue
French
Weight
437 KB
Volume
11
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

^14^C‐labelled carbon tetrachloride binds in vivo to DNA of mouse liver and to ^r^RNA of rat liver if the animals have been pretreated with 3‐methylcholanthrene. A noticeable amount of radioactivity is also observed in liver proteins. In vitro carbon tetrachloride is activated by microsomes and pH 5 enzymes of 3‐methylcholanthrene‐treated animals to a metabolite which can react with DNA and polynucleotides; this effect is more evident if subcellular fractions from mouse liver are used.

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