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Effects of penicillins on binding of phenytoin to plasma proteins in vitro and in vivo

✍ Scribed by K. Arimori; M. Nakano; M. Otagiri; K. Uekama

Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
397 KB
Volume
5
Category
Article
ISSN
0142-2782

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✦ Synopsis

Effects of penicillins on the binding of phenytoin to plasma proteins were examined in vitro and in uivo. The results from in uitro studies showed that the penicillins including oxacillin and dicloxacillin were effective in displacing phenytoin from its binding sites. I n uivo, the total phenytoin concentration in serum decreased during penicillin administration, while the free phenytoin concentration increased. As a result, penicillins caused a significant increase in the apparent volume of distribution and in the total body clearance of phenytoin. These results can be explained on the basis of the displacement of phenytoin from its plasma protein binding site by penicillins.

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