Both iodine-123-labeled โค-CIT (2โค-carbomethoxy-3โค-(4-iodophenyl)tropane) and nor-โค-CIT (2โค-carbomethoxy-3โค-(4-iodophenyl)nortropane) have shown to be suitable radioligands for imaging serotonin (5-HT) transporters. [ 123 I]nor-โค-CIT has the highest in vitro affinity for 5-HT transporters among โค-CIT
Selective in vitro and in vivo binding of [125I]ADAM to serotonin transporters in rat brain
โ Scribed by Seok-Rye Choi; Catherine Hou; Shunichi Oya; Mu Mu; Mei-Ping Kung; Michael Siciliano; Paul D. Acton; Hank F. Kung
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 186 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0887-4476
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๐ SIMILAR VOLUMES
The effects of MK-801, a noncompetitive NMDA receptor antagonist, on in vivo and in vitro binding of radioactive iodine ([ 123 I] or [ 125 I]) labeled โค-CIT [RTI-55, 3โค-(4-iodophenyl)tropane-2โค-carboxylic acid methyl ester] were investigated in rat brain. In the in vitro binding study, 10 pM of [ 12
Diffusion measurements were performed on the N-acetyl aspartate (NAA) signal in in situ brains (in vivo and post-mortem) and on in vitro brain tissue at 37 ยฐC using wide ranges of b-values (from 0 up to 4.5 ร 10 6 s/cm 2 and 35.8 ร 10 6 s/cm 2 for the in vivo and the in vitro cases, respectively). I