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Mutagenicity and cytotoxicity of congeners of two classes of nitroso compounds in chinese hamster ovary cells

โœ Scribed by David B. Couch; Abraham W. Hsie


Book ID
113191490
Publisher
Elsevier Science
Year
1978
Tongue
English
Weight
450 KB
Volume
57
Category
Article
ISSN
0027-5107

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A strong teratogen-6-aminonicotinamide (6-AN)-was tested for its ability to induce cytotoxicity and mutagenicity in Chinese hamster ovary (CHO) cells. Tests were performed in the presence and absence of a metabolic activation system (S-9 mix). Cytotoxicity was evaluated in CHO cells by the total pro