Murine Models of Paroxysmal Nocturnal Hemoglobinuria
โ Scribed by VITTORIO ROSTI
- Book ID
- 111397485
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 197 KB
- Volume
- 963
- Category
- Article
- ISSN
- 0890-6564
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Paroxysmal nocturnal hemoglobinuria (PNH) is a rare clonal stem-cell disorder in which blood cells lack complement inhibiting membrane proteins, and become susceptible to complement-mediated injury, leading to chronic intravascular hemolysis and pancytopenia. Glucocorticoids have been a mainstay of
A case of a patient who developed erythroleukemia 3 years into the course of paroxysmal nocturnal hemoglobinuria (PNH) is presented. A case of erythroleukemia with a positive sucrose lysis test has been reported, but our case appears to be the first with a long clinical course of PNH evolving into e