Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal hematopoietic stem cell disorder characterized by an intravascular hemolytic anemia. Abnormal blood cells lack a series of glycosylphosphatidylinositol (GPI)-anchored proteins. The lack of GPIanchored complement regulatory proteins, suc
Molecular Genetics of Paroxysmal Nocturnal Hemoglobinuria
โ Scribed by Norimitsu Inoue; Yoshiko Murakami; Taroh Kinoshita
- Publisher
- Carden Jennings Publishing
- Year
- 2003
- Tongue
- English
- Weight
- 357 KB
- Volume
- 77
- Category
- Article
- ISSN
- 0925-5710
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare clonal stem-cell disorder in which blood cells lack complement inhibiting membrane proteins, and become susceptible to complement-mediated injury, leading to chronic intravascular hemolysis and pancytopenia. Glucocorticoids have been a mainstay of
A case of a patient who developed erythroleukemia 3 years into the course of paroxysmal nocturnal hemoglobinuria (PNH) is presented. A case of erythroleukemia with a positive sucrose lysis test has been reported, but our case appears to be the first with a long clinical course of PNH evolving into e