Multivariate Analysis of the Sequence Dependence of Asparagine Deamidation Rates in Peptides
β Scribed by Andrew A. Kosky; Vasumathi Dharmavaram; Gayathri Ratnaswamy; Mark Cornell Manning
- Book ID
- 106493834
- Publisher
- Springer US
- Year
- 2009
- Tongue
- English
- Weight
- 365 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0724-8741
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π SIMILAR VOLUMES
Asparagine (Asn) degradation kinetics in two model peptides, Gly-Gln-Asn-Gly-Gly (GQNGG) and Val-Tyr-Pro-Asn-Gly-Ala (VYPNGA), were studied at 50 degrees C in pH 7 buffer solutions in the presence and absence of 5% (w/v) sucrose or mannitol and at 50 degrees C and 30% relative humidity in solid samp
Our objective was to compare the relative rates of asparaginyl and glutaminyl deamidation in fragment 22-29 of the polypeptide hormone glucagon in acidic aqueous solutions. Reaction mixtures containing 22-29 (FVQWLMNT) or its degradation products were degraded at 60 degrees C in dilute hydrochloric