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Multiple mechanisms of action of azelaic acid: New findings

Book ID
116584930
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
41 KB
Volume
60
Category
Article
ISSN
1097-6787

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Azelaic acid, and other saturated dicarboxylic acids (C9-C12), are shown to be competitive inhibitors of tyrosinase (KI azelaic acid = 2.73 X 10(-3) M) and of membrane-associated thioredoxin reductase (KI azelaic acid = 1.25 X 10(-5) M). The monomethyl ester of azelaic acid does not inhibit thioredo