New drugs in multiple myeloma: mechanisms of action and phase I/II clinical findings
✍ Scribed by Enrique M Ocio; María-Victoria Mateos; Patricia Maiso; Atanasio Pandiella; Jesús F San-Miguel
- Book ID
- 117784879
- Publisher
- The Lancet
- Year
- 2008
- Tongue
- English
- Weight
- 531 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1470-2045
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In patients with multiple myeloma, there is preclinical justification to combine arsenic trioxide (ATO and As 2 O 3 ) with DVd (Doxil TM , vincristine, and dexamethasone) for newly diagnosed patients. Eleven patients on this phase II trial received 0.15 mg/kg of ATO for five consecutive days followe
## Abstract ## BACKGROUND Multiple myeloma remains an incurable disease. New agents are needed to improve therapy for patients with this disease. Previous investigators evaluated in vitro sensitivity of myeloma cells to polyethylene glycol‐conjugated L‐asparaginase (PEG‐L‐asparaginase) using the h