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Implications of azelaic acid's multiple mechanisms of action: Therapeutic versatility

Book ID
116583611
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
48 KB
Volume
58
Category
Article
ISSN
1097-6787

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Azelaic acid, and other saturated dicarboxylic acids (C9-C12), are shown to be competitive inhibitors of tyrosinase (KI azelaic acid = 2.73 X 10(-3) M) and of membrane-associated thioredoxin reductase (KI azelaic acid = 1.25 X 10(-5) M). The monomethyl ester of azelaic acid does not inhibit thioredo