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Azelaic Acid: Properties and Mode of Action

โœ Scribed by Sieber, M.A.; Hegel, J.K.E.


Book ID
121714139
Publisher
S. Karger AG
Year
2014
Tongue
English
Weight
887 KB
Volume
27
Category
Article
ISSN
1422-2868

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A possible mechanism of action for azela
โœ K. U. Schallreuter; J. W. Wood ๐Ÿ“‚ Article ๐Ÿ“… 1990 ๐Ÿ› Springer-Verlag ๐ŸŒ English โš– 480 KB

Azelaic acid, and other saturated dicarboxylic acids (C9-C12), are shown to be competitive inhibitors of tyrosinase (KI azelaic acid = 2.73 X 10(-3) M) and of membrane-associated thioredoxin reductase (KI azelaic acid = 1.25 X 10(-5) M). The monomethyl ester of azelaic acid does not inhibit thioredo