Multiple antiepileptic drugs and plasma levels of carbamazepine and carbamazepine-10,11-epoxide
β Scribed by Zhi Ye Xiang
- Book ID
- 119173460
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 122 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0887-8994
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π SIMILAR VOLUMES
## Carbamazepine (Tegretol", CBZ) is an anticonvulsant drug that is very effective in the treatment of tonic-clonic seizures and is gaining acceptance as a treatment for various psychiatric disorders. The drug is embryotoxic in rodents and has been reported to produce neural tube defects in approx
Carbamazepine-lO,l l-epoxide is a metabolite of carbamazepine that has been identified in the urine OT the rat and in the urine and plasma of marV and which, in the rat, has been shown to have antiepileptic properties comparable to those of the parent drug. It has therefore been suggested3 that, in