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In vitro embryotoxicity of carbamazepine and carbamazepine-10,11-epoxide

✍ Scribed by Hansen, Deborah K.; Dial, Stacey L.; Terry, Ketti K.; Grafton, Thomas F.

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
695 KB
Volume
54
Category
Article
ISSN
0040-3709

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✦ Synopsis

Carbamazepine

(Tegretol", CBZ) is an anticonvulsant drug that is very effective in the treatment of tonic-clonic seizures and is gaining acceptance as a treatment for various psychiatric disorders. The drug is embryotoxic in rodents and has been reported to produce neural tube defects in approximately 1 % of prenatally exposed human offspring. It is metabolized by the cytochrome P-450 system to a stable, pharmaco-'93). A recent case-control study found a n excess of in-

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